Dr Salahuddin Kazi, MD, comments on the challenges of diagnosing seronegative rheumatic diseases and discusses a case presentation that highlights these difficulties.

We spoke with Mark Richardson, MD, PhD, and John Tesser, MD, to discuss vagus nerve stimulation for the treatment RA and results of the pivotal RESET-RA trial.

J Eugene Huffstutter, MD, and Robert G Hylland, MD, discuss the evolving concept of frailty in rheumatology.

The exact definition of difficult-to-treat rheumatoid arthritis has been the subject of debate due to the heterogeneous patient population.

In part 2 of this series, Swamy Venuturupalli, MD, and Beth Darnall, PhD, discuss the current research on the use of digital therapeutics for managing chronic pain.